Sneha Grandhi, Ph.D. joined Genscience as a Translational Geneticist in 2025 to support disease- and modality-agnostic drug target identification and prioritization using human genetics. Sneha leverages over a decade of experience in statistical and translational genetics, evolutionary genomics, and bioinformatics to drive strategic decision-making in drug discovery. Prior to Genscience, Sneha was a Senior Manager of Genetics at Pfizer’s external-facing Emerging Sciences and Innovation division and a postdoctoral research fellow in the Department of Genetics at Harvard Medical School.

Selected Publications

Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection

Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase

Increased FAN1 expression by mRNA-LNP attenuates CAG repeat expansion in Huntington patients’ iPSC-derived astrocytes